Get the relief you need.

Answer a few questions so that we can direct you toward getting better migraine care faster.
  • Precision care treatment plan
  • Expert doctor diagnosis & prescription
  • Affordable & no insurance required
  • 100% satisfaction guarantee

Get Better with Clinically
Proven Treatment Tailored to You

We recommend Mable to people who have tried less than 4 preventative migraine treatments and have not been prescribed CGRP inhibitors before.

Precision care using Mable’s DNA test is built specifically for people who are interested in preventative treatments in addition to acute medication.

If your dedicated doctor decides upon the first review of your information that Mable is not a good fit for you, you’ll get a 100% refund.
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1

Take Mable’s DNA Test

Our DNA test is a fast, easy, and painless cheek swab that you can take at home. Mapping your DNA helps us identify which preventative migraine treatments will be best suited for you.
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2

Complete our online medical assessment

This short consultation will help us better understand your migraine and medical history.
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3

Receive a personalized plan

Your doctor will create the treatment plan suiting you best using the latest advances in genomic and clinical research. Treatment plans include acute, preventative and anti-nausea medications as well as supplements.
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4

Get treatments delivered to your door

Mable delivers treatments to your door every three months in time before you run out of supply.
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5

Keep getting better

Get regular medical follow-ups, access to your doctor within hours and continuous improvements to your treatment plan.
100% data privacy
We do not sell your data. We do not share your data with third parties other than for the sole purpose of analyzing, creating and fulfilling your personalized treatment plan. Samples collected through our at-home DNA test are analyzed in ISO and CLIA certified labs.
Continuous treatment improvements: after you receive your initial treatment plan, we keep screening your migraine and genetic information to match you with better treatment options once new evidence becomes available. Treatment improvements are included in your membership. You and your doctor will be notified. Our goal is to ensure that you always receive the best migraine care possible.

After you accept your treatment plan (you'll be notified via email), we ship a 90-day supply of your medication direct to your door. Payments are billed every 30 days after initial order. Memberships auto-renew every three months. Easy cancellation.

100% refund guarantee if no treatment recommendation can be issued or you are not happy with Mable.
Scientific rigor.
To ensure the scientific rigor of our testing process, we only use scientifically backed pharmacogenetic markers published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC). We regularly update our testing menu, once new solid scientific evidence becomes available.
Preventative medications.
In headache specialist clinics, most preventative migraine medications are prescribed "off-label". For instance, certain beta-blockers or antidepressants are routinely used to treat migraines. These medications have well documented pharmacogenetic associations and Mable enables physicians to leverage these to guide treatment based on DNA.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These help reduce nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These are taken at the onset of a migraine attack to stop or reduce the pain. There are some painkillers that are highly specific for migraines. These include many different triptans such as Zolmitriptan, Almotriptan, Rizatriptan, Frovatriptan and Naratriptan. For this group of medications, there are no known genetic markers available to date. Fortunately, the choice of acute treatment can be informed by your specific migraine symptoms and medical history.
CGRP inhibitors (monoclonal antibodies).
CGRP (Calcitonin Gene-Related Peptide) inhibitors are a new class of medications to prevent and treat acute migraine pain. To date, there are no well established genetic markers to help predict a person's response to this group of medications. Mable and academic institutions are intensely researching this new field of migraine care and we will incorporate CGRP inhibitors into our testing process once strong scientific evidence becomes available.
Mable's test looks for 350+ SNPs (single nucleotide polymorphisms) that impact your body's response to migraine medications. This approach is called pharmacogenetic testing. Mable uses exclusively scientifically backed pharmacogenetic associations published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Knowledge of a patient's genotype can be used to guide a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. We found that 60% of people with migraine have a genetic predisposition that would warrant caution with 8 or more standard migraine medications.

Mable's platform enables physicians for the first time to contextualize this pharmacogenetic information with your unique migraine symptoms in order to create a personalized treatment plan in accordance with your unique physiology.

How Mable Is Different

Mable
  • Specialized Migraine Care
    Mable ONLY treats migraine
  • Regular Check-Ins
    Your dedicated physician team proactively and regularly reaches out to ensure you get what you need
  • Prescriptions
    Get proven, FDA-approved medications
    Generic meds starting from $21 per month. Shipped directly to your door
  • Transparent Pricing
    Whether you use insurance or pay cash, Mable always discloses costs in advance
    Initial consult up to $49
  • Thorough Consultation
    Mable's online consultation is as thorough as an in-person medical provider visit
  • Unlimited Doctor Access
    Message your dedicated clinical team at any time for adjustments, advice, or questions
  • 100% satisfaction guarantee
    Full refund guarantee if no treatment recommendation can be issued or you are not happy with Mable
Doctor
  • Specialized Migraine Care
    Not enough experience to treat migraine
  • Regular Check-Ins
    No regular follow-ups unless you schedule another in-person visit with your doctor for an additional fee
  • Prescriptions
    Get proven, FDA-approved medications
    Prices vary.
    Extra trip to the pharmacy
  • Transparent Pricing
    Cost of the visit and cost of the treatment usually come as a surprise
    Up to $300 per visit
  • Thorough Consultation
    Doctor's consultations are usually limited in time and do not give you flexibility
  • Unlimited Doctor Access
    To ask a simple question you need to schedule in-person visit and pay an additional fee
  • 100% satisfaction guarantee
    Doctor will not refund you if the selected treatment didn't work or you are unhappy with the results
Mable
Doctor
Specialized Migraine Care
Mable ONLY treats migraine
Regular Check-Ins
Your dedicated physician team proactively and regularly reaches out to ensure you get what you need
Prescriptions
Get proven, FDA-approved medications
Generic meds starting from $5 per month: shipped directly to your door
Prices vary; extra trip to the pharmacy
Transparent Pricing
Whether you use insurance or pay cash, Mable always discloses costs in advance
Initial consult up to $49
Up to $300 per visit
Thorough Consultation
Mable's online consultation is as thorough as an in-person medical provider visit
Unlimited Doctor Access
Message your dedicated clinical team at any time for adjustments, advice, or questions
100% satisfaction guarantee
Full refund guarantee if no treatment recommendation can be issued or you are not happy with Mable.
No commitment.
Cancel at any time.

Mable's Medical Board
Renowned migraine specialists

Peter Goadsby
Carolyn Bernstein
Morris Levin
Olivia Begasse De Dhaem

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Frequently asked questions

Why is Mable's approach faster and cheaper
than the traditional route to migraine treatment?
What happens during DNA-guided treatment step by step?
How does DNA-informed treatment work?
Who may not be a suitable candidate for the Mable treatment plan?
Does Mable sell my DNA to third parties? (No, we don’t!)
Can I get personalized Migraine Care without
the DNA-informed treatment plan?
Which conditions and medications are supported?
Can I use insurance to pay for Mable?
Membership details
How do refills work?
What states does Mable currently serve?
Should I cancel my prescriptions when I sign up for Mable?
Is Mable covered under HIPAA?
Can I use my FSA or HSA for payment?

Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.