Doctor-recommended and scientifically backed treatment
Physicians on Mable leverage migraine health-data from thousands of people like you that have already found the right treatment. Get matched and get treatment that works for you.
Tell us about your migraines and we match you up with treatment data insights from thousands of people like you. Your doctor creates your personalized treatment plan accordingly.
2
2
We deliver your treatment
Approve your treatment plan and get your recommended treatment delivered to your door.
3
3
Keep getting better
Get personalized treatment instructions, regular follow-ups and access to your doctor and nurse team. We notify you and your doctor very time treatment options that may be a better fit for you emerge. Treatment changes included.
Increase the precision of your prescription with our migraine treatment test. Mable analyses your DNA for 350+ unique factors that impact how your body responds to different treatments.
We recommend Mable to people who have tried less than 4 preventative migraine treatments and have not been prescribed CGRP inhibitors before.
Precision care using Mable’s DNA test is built specifically for people who are interested in preventative treatments in addition to acute medication.
If your dedicated doctor decides upon the first review of your information that Mable is not a good fit for you, you’ll get a 100% refund.
1
Take Mable’s DNA Test
Our DNA test is a fast, easy, and painless cheek swab that you can take at home. Mapping your DNA helps us identify which preventative migraine treatments will be best suited for you.
2
Complete our online medical assessment
This short consultation will help us better understand your migraine and medical history.
3
Receive a personalized plan
Your doctor will create the treatment plan suiting you best using the latest advances in genomic and clinical research. Treatment plans include acute, preventative and anti-nausea medications as well as supplements.
4
Get treatments delivered to your door
Mable delivers treatments to your door every three months in time before you run out of supply.
5
Keep getting better
Get regular medical follow-ups, access to your doctor within hours and continuous improvements to your treatment plan.
100% data privacy
We do not sell your data. We do not share your data with third parties other than for the sole purpose of analyzing, creating and fulfilling your personalized treatment plan. Samples collected through our at-home DNA test are analyzed in ISO and CLIA certified labs.
Continuous treatment improvements: after you receive your initial treatment plan, we keep screening your migraine and genetic information to match you with better treatment options once new evidence becomes available. Treatment improvements are included in your membership. You and your doctor will be notified. Our goal is to ensure that you always receive the best migraine care possible.
After you accept your treatment plan (you'll be notified via email), we ship a 90-day supply of your medication direct to your door. Payments are billed every 30 days after initial order. Memberships auto-renew every three months. Easy cancellation.
100% refund guarantee if no treatment recommendation can be issued or you are not happy with Mable.
In headache specialist clinics, most preventative migraine medications are prescribed "off-label". For instance, certain beta-blockers or antidepressants are routinely used to treat migraines. These medications have well documented pharmacogenetic associations and Mable enables physicians to leverage these to guide treatment based on DNA.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These help reduce nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These are taken at the onset of a migraine attack to stop or reduce the pain. There are some painkillers that are highly specific for migraines. These include many different triptans such as Zolmitriptan, Almotriptan, Rizatriptan, Frovatriptan and Naratriptan. For this group of medications, there are no known genetic markers available to date. Fortunately, the choice of acute treatment can be informed by your specific migraine symptoms and medical history.
CGRP inhibitors (monoclonal antibodies).
CGRP (Calcitonin Gene-Related Peptide) inhibitors are a new class of medications to prevent and treat acute migraine pain. To date, there are no well established genetic markers to help predict a person's response to this group of medications. Mable and academic institutions are intensely researching this new field of migraine care and we will incorporate CGRP inhibitors into our testing process once strong scientific evidence becomes available.
Mable's test looks for 350+ SNPs (single nucleotide polymorphisms) that impact your body's response to migraine medications. This approach is called pharmacogenetic testing. Mable uses exclusively scientifically backed pharmacogenetic associations published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC). Knowledge of a patient's genotype can be used to guide a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. We found that 60% of people with migraine have a genetic predisposition that would warrant caution with 8 or more standard migraine medications.
Mable's platform enables physicians for the first time to contextualize this pharmacogenetic information with your unique migraine symptoms in order to create a personalized treatment plan in accordance with your unique physiology.
What renowned migraine specialists are saying about Mable
Carolyn Bernstein
MD, FAHS
Author of The Migraine Brain
“
Mable's evidence based approach is what migraine care needs...
One of the biggest challenges for headache specialists is to determine which medications are best suited for an individual patient. Mable's evidence based approach is what migraine care needs. The Mable team leverages scientific evidence to bridge the the gap in best-practice decision making around migraine medications via a telehealth platform.
“
Patients and their doctors have to go through a trial-and-error process...
The challenge that migraine patients and their doctors have long had is that they have to go through a trial-and-error process to discover best treatments. Every step takes a certain number of weeks to months, and the delay can be highly frustrating. If we had a way to predict which patients would tolerate and benefit from which treatment options, patients would be much happier and we'd have more success - and more quickly.
Morris Levin
MD, FAHS
Author of Understanding Your Migraines
Olivia Begasse De Dhaem
MD, FAHS
Executive Editor for the Pain Medicine Journal
“
Migraine is still underdiagnosed and undertreated...
There is a shortage of headache specialists. There are many barriers to accessing proper treatments and it takes time and trial and error to find the best personalized treatment for each individual. Mable's program is designed to make quality migraine care broadly accessible to the general public and aims at improving the use of genetic testing for personalized migraine care. I am proud to be working with the team to help bring Mable into primary care. This will help improve patient outcomes and reduce strain on our overburdened healthcare system.
Mable's Treatment Plans
100% refund guarantee if Mable is not a fit for you.
Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.
