Doctor-recommended and scientifically backed treatment
Physicians on Mable leverage migraine health-data from thousands of people like you that have already found the right treatment. Get matched and get treatment that works for you.
Tell us about your migraines and we match you up with treatment data insights from thousands of people like you. Your doctor creates your personalized treatment plan accordingly.
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We deliver your treatment
Approve your treatment plan and get your recommended treatment delivered to your door.
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Keep getting better
Get personalized treatment instructions, regular follow-ups and access to your doctor and nurse team. We notify you and your doctor very time treatment options that may be a better fit for you emerge. Treatment changes included.
Increase the precision of your prescription with our migraine treatment test. Mable analyses your DNA for 350+ unique factors that impact how your body responds to different treatments.
We recommend Mable to people who have tried less than 4 preventative migraine treatments and have not been prescribed CGRP inhibitors before.
Specialized Care: If you are on a budget, we recommend our "Specialized Care" package, which gives you data-driven and specialist-backed migraine care from home. You will receive prescriptions for acute, preventative and anti-nausea medications. Precision Care: If you want to dive deep into which preventative treatments are most likely to work for you and minimize the risk of side effects, we recommend our "Precision Care" pathway. This gives your dedicated doctor team an unprecedented amount of detail to adjust your treatment to your migraine symptoms and body. Our migraine treatment test is scans your entire genome and is built specifically to test for a range of the most commonly prescribed preventative treatments.
If you are unhappy with Mable, you’ll get a 100% refund.
Our partnering doctors work with Mable to leverage health-data from large-scale clinical trials and insights from thousands of patients to match you with your treatment. You will be matched with your dedicated doctor and nurse team licensed in your area. Communication with your doctor and nurse-team happens online. You will receive medical follow-ups every 2-4 weeks depending on your treatment plan via email. Call your medical team or email them to receive support within 24h.
In headache specialist clinics, most preventative migraine medications are prescribed "off-label". For instance, certain beta-blockers or antidepressants are routinely used to treat migraines. These medications have well documented pharmacogenetic associations and Mable enables physicians to leverage these to guide treatment based on DNA.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These help reduce nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These are taken at the onset of a migraine attack to stop or reduce the pain. There are some painkillers that are highly specific for migraines. These include many different triptans such as Zolmitriptan, Almotriptan, Rizatriptan, Frovatriptan and Naratriptan. For this group of medications, there are no known genetic markers available to date. Fortunately, the choice of acute treatment can be informed by your specific migraine symptoms and medical history.
CGRP inhibitors (monoclonal antibodies).
CGRP (Calcitonin Gene-Related Peptide) inhibitors are a new class of medications to prevent and treat acute migraine pain. To date, there are no well established genetic markers to help predict a person's response to this group of medications. Mable and academic institutions are intensely researching this new field of migraine care and we will incorporate CGRP inhibitors into our testing process once strong scientific evidence becomes available.
Mable's test looks for 350+ SNPs (single nucleotide polymorphisms) that impact your body's response to migraine medications. This approach is called pharmacogenetic testing. Mable uses exclusively scientifically backed pharmacogenetic associations published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC). Knowledge of a patient's genotype can be used to guide a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. We found that 60% of people with migraine have a genetic predisposition that would warrant caution with 8 or more standard migraine medications.
Mable's platform enables physicians for the first time to contextualize this pharmacogenetic information with your unique migraine symptoms in order to create a personalized treatment plan in accordance with your unique physiology.
Is Mable right for me?
Who are my doctors?
Which medications does Mable's DNA test cover?
How are my genes related to medications?
What renowned migraine specialists are saying about Mable
Carolyn Bernstein
MD, FAHS
Author of The Migraine Brain
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Mable's evidence based approach is what migraine care needs...
One of the biggest challenges for headache specialists is to determine which medications are best suited for an individual patient. Mable's evidence based approach is what migraine care needs. The Mable team leverages scientific evidence to bridge the gap in best-practice decision making around migraine medications via a telehealth platform.
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Patients and their doctors have to go through a trial-and-error process...
The challenge that migraine patients and their doctors have long had is that they have to go through a trial-and-error process to discover best treatments. Every step takes a certain number of weeks to months, and the delay can be highly frustrating. If we had a way to predict which patients would tolerate and benefit from which treatment options, patients would be much happier and we'd have more success - and more quickly.
Morris Levin
MD, FAHS
Author of Understanding Your Migraines
Olivia Begasse De Dhaem
MD, FAHS
Executive Editor for the Pain Medicine Journal
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Migraine is still underdiagnosed and undertreated...
There is a shortage of headache specialists. There are many barriers to accessing proper treatments and it takes time and trial and error to find the best personalized treatment for each individual. Mable's program is designed to make quality migraine care broadly accessible to the general public and aims at improving the use of genetic testing for personalized migraine care. I am proud to be working with the team to help bring Mable into primary care. This will help improve patient outcomes and reduce strain on our overburdened healthcare system.
Mable's Treatment Plans
100% refund guarantee if Mable is not a fit for you.
Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.
THE ESSENTIALS
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Specialized care
Most affordable expert care
Expert doctor diagnosis & prescription
HSA/FSA eligible
Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.
100% online so you're always in control
Give your clinical team more information about your medical history and migraine to ensure your desired medication is still a fit.
