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How Mable Works

What is Mable?

Your migraines are not like anyone else’s, so how your body responds to migraine treatment is unique to you.

Finding a migraine treatment specifically suited to you can be a process of trial-and-error that continues for months, even years. But Mable can point you to the right treatment much more quickly.
 
We developed the first comprehensive test that tailors treatment to your genes and how they affect your body’s response to available migraine treatments. We consider every vital factor about you — your DNA, family and personal medical history, current lifestyle — to help determine the migraine treatment most suited to your needs, then offer you beneficial, ongoing migraine care.

How does Mable DNA testing work?

Here’s a simple step-by-step summary of how Mable works:

1. Complete our 2-minute quiz to see if our DNA testing is a good fit for you. It’s typically an effective approach for people who:

Experience three or more migraines per month or have very severe migraines.
Are willing to take daily preventative medication to reduce the frequency and severity of migraine attacks.
Are committed to preventing their migraines by following their Migraine Care plan.

2. Order our DNA kit. By evaluating your DNA, our doctors can accurately tailor treatments with the greatest potential to help you. Your DNA-informed treatment plan can specify the preventative treatments with the best chance to stop your migraines from happening and reduce your level of pain.

3. Use your Mable DNA kit to collect your DNA sample saliva swab in 10 seconds.

4. Place your sample swab in the shipper box included with your DNA kit, and attach the pre-paid, pre-addressed return label. Then simply place the box in your mailbox or drop it at your nearest post office or shipping center. 

5. When Mable receives your sample, we carefully map your genetic data to see how you’re likely to respond to a variety of different migraine treatment options. After we select specific treatment options based on your unique migraine history and DNA, our partner migraine care specialists use this information to create a Precision Care Plan individualized to you.

If you are satisfied with your individualized treatment plan, you may then opt to have medications delivered directly to your door. Then through our app, you can stay connected to Mable, for continuous expert care.

Can I get personalized Mable Migraine Care without the DNA test?
How is it different?

Yes, based on information you provide in our online assessment, we can certainly offer you a robust Specialized Care plan that includes both preventive and acute migraine treatment, as well as anti-nausea CGRP medications, and supplements.

But there is an important difference between our Precision Care plan (with DNA test) and our Specialized Care plan (without DNA test):

With Precision Care, your simple cheek swab gives us valuable information on which preventative and anti-nausea medication may suit you best. We test your DNA against dozens of treatments and can eliminate options upfront that may not work for you, potentially bringing you faster relief by speeding up your preventative migraine care while reducing side effects. (One note: presently, DNA testing will not help with the choice of acute medications, which is based on currently available research and FDA guidelines.)

We recommend trying the DNA testing approach via Precision Care! However, whether you decide to choose Precision Care or select Specialized Care, Mable is here to support you.

How do I know if Mable might be a good fit for me?

Mable offers treatment plans only for migraine with aura, migraine without aura, and menstrual migraine. We do not currently offer treatment plans for vestibular, hemiplegic, ophthalmic, abdominal, or brainstem aura migraine. 

Mable is a good fit for you if you:
— Are unsure about your headache diagnosis.
— Know that you have migraines and want to begin migraine medication.
— Want to change your current migraine medication to something more effective.

You may not be suitable for a Mable treatment plan if you:
— Have previously used, or currently use, advanced preventative treatments, including calcitonin gene-related peptide (CGRP) inhibitors such as Rimegepant (Nurtec ODT), Galcanezumab (Emgality), Atogepant (Qulipta), Erenumab (Aimovig), Eptinezumab (Vyepti), or Fremanezumab (Ajovy).
— Have previously tried more than four preventative migraine medications which have not worked for you.
— Are a migraine patient requiring in-person examination and treatment from a neurologist, require botox treatment, or require blood tests for further treatment.

Where is Mable currently available?

We currently serve members who live in the following states: Alabama, Arkansas, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Massachusetts, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Mexico, New York (Specialized Care plan only), North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming. 

Don’t see your state?
Mable is coming to more locations soon.
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Will Mable sell my data to third parties?

No, Mable will never sell your data to third parties, and we don’t share your genetic or clinical data with insurance providers. Unlike other companies in our industry, Mable simply uses your information to individualize your treatment and further improve our ability to provide DNA-informed treatment plans.

We take your privacy seriously.
Research in this area is still very new, and Mable’s internal efforts aim to continuously advance the care we provide to you and patients like you. For research purposes, your data is treated anonymously. It is encrypted using industry-standard encryption methods and stored securely on Mable servers. We minimize any risk of your data being exposed by strictly controlling who at Mable may access sensitive customer data. Any data passed to external service providers, outside of your physician, is anonymized to remove any reference to you as an individual.

We may collaborate with accredited external parties, such as universities, hospitals, health systems, government institutions, or private companies. Collaboration only occurs for research purposes in a secure environment. No data is ever sold to third-party providers. To opt out of such research, contact Mable at support@trymable.com.

Medication & Treatment

Which medications does Mable consider when creating my individualized treatment plan?
Preventative medications.
Most of these medications are taken daily in pill form to help prevent migraine. Genetic factors influence how your body may react to several key treatment options below, which are listed in the FDA pharmacogenetic table.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These medications help reduce the nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These medications are taken at the onset of a migraine attack, to stop or reduce the pain. Mable considers different types of painkillers specifically developed for migraine treatment, including triptans like Almotriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, and Zolmitriptan, as well as CGRP antagonists such as Nurtec. For this group of medications, genetic markers are unknown to date, but choice of acute treatment can be informed by your specific migraine symptoms.
CGRP inhibitors (monoclonal antibodies).
CGRP inhibitors are a new class of medications aimed at preventing and treating acute migraine pain. To date, there are no well established genetic markers that help predict a person's response to CGRPs. Mable and academic institutions are intensely researching this new field of migraine care; we will incorporate CGRP inhibitors into our testing process if and when we see a strong connection to genetic markers.
Should I cancel my existing prescriptions when I sign up for Mable?

After you sign up with Mable, we advise you to wait a few weeks before canceling any previous prescriptions. 

How do refills work?

You will receive your prescription medication quarterly, direct to your door and discreetly packaged. 

As your migraine treatment plan progresses, you'll receive updates to your plan that you may need to confirm before a refill or a new prescription is shipped to you. You will also receive updates as enhanced treatments become available.

How is Mable’s approach more effective than the traditional approach to migraine management?

Mabel offers streamlined migraine diagnosis and treatment with the help of world-leading experts in migraine care. We can provide a quick and effective treatment, based on the latest evidence and clinical practice and delivered right to your door.

You may typically wait as long as six months for an in-person appointment with a headache specialist. By comparison, Mable can review your case and send treatment within 24-48 hours or as soon as your DNA-informed treatment plan results are complete.

Who are my doctors?
What is the relationship between Mable and my current doctor?

Insurance & Payment

Is Mable covered under HIPAA?

Yes, Mable is HIPAA compliant.

Will my insurance cover Mable?

Mable is not currently covered by insurance.

Can I use my FSA or HSA for payment?

Both the Precision Care plan and Standardized Care plan and related medications are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, check with yours to confirm that the Mable test qualifies. Contact us at support@trymable.com for an itemized receipt.

Have other questions? 

Visit our Help Center to see additional Frequently Asked Questions
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Reach out to our support team at +1 (888) 234-5212
Email us at support@trymable.com