It's not all in your head.

Mable reduces your migraines by individualizing treatment to your DNA.

See if it works for you.
Mable Migraine Treatment Test PhotoMable Migraine Treatment Test Photo

With support from

Current migraine care often leads to a long trial-and-error process. Mable's team understands that the key to effective relief relies upon individualized treatment guided by a person's unique DNA and experience.
Dr. Carolyn Bernstein
Harvard Medical School
Mable Medical Board Member
Dr. Carolyn Bernstein - Mable Medical Board Member.

No one size fits all treatment.
Mable is one size fits you.

Your genes determine how your body responds to different types of medications. For the first time, Mable's platform enables physicians to jointly analyze your unique migraine symptoms and genetics in order to create a migraine treatment plan tailored to you. This way, Mable maximizes your chances of success and minimizes the risk of side effects. We work together with renowned experts from Harvard, University of California San Francisco and Los Angeles.
After you accept your treatment plan (you'll be notified via email), we ship a 90-day supply of your medication direct to your door. Payments are billed every 30 days after initial order. Memberships auto-renew every three months. Easy cancellation.
Preventative medications.
In headache specialist clinics, most preventative migraine medications are prescribed "off-label". For instance, certain beta-blockers or antidepressants are routinely used to treat migraines. These medications have well documented pharmacogenetic associations and Mable enables physicians to leverage these to guide treatment based on DNA.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These help reduce nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These are taken at the onset of a migraine attack to stop or reduce the pain. There are some painkillers that are highly specific for migraines. These include many different triptans such as Zolmitriptan, Almotriptan, Rizatriptan, Naratriptan, and CGRP-treatments such as Nurtec. For this group of medications, there are no known genetic markers available to date. Fortunately, the choice of acute treatment can be informed by your specific migraine symptoms and medical history.
Mable's test looks for 350+ SNPs (single nucleotide polymorphisms) that impact your body's response to migraine medications. This approach is called pharmacogenetic testing. Mable uses exclusively scientifically backed pharmacogenetic associations published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Knowledge of a patient's genotype can be used to guide a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. We found that 60% of people with migraine have a genetic predisposition that would warrant caution with 8 or more standard migraine medications.

Mable's platform enables physicians for the first time to contextualize this pharmacogenetic information with your unique migraine symptoms in order to create a personalized treatment plan in accordance with your unique physiology.
We do not sell your data. We do not share your data with third parties other than for the sole purpose of analyzing, creating and fulfilling your personalized treatment plan. Samples collected through our at-home DNA test are analyzed in ISO and CLIA certified labs.
Get better with clinically proven
treatment tailored to you.

Get better with clinically proven
treatment tailored to you.

Mable’s Treatment Plans

HSA/FSA Eligible
Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.
POPULAR

DNA-guided specialist care

  • Individualized treatment plan based on your DNA and your unique migraine experience.
  • Shorten the path to migraine care that actually works for you.
  • mable checklist item
    Avoid potential years of trial-and-error looking for preventative medication.
  • Eliminate time-consuming doctor visits and get continuous treatment plan improvements.
  • Regular clinical follow-ups to help you stay on track and keep getting better.
  • Track symptoms, medications and progress.
  • Including rushed shipping to your door, return labels, DNA analysis, and individualized treatment plan.
$329
once

Specialist care

  • Individualized treatment plan based on your unique migraine experience.
  • Eliminate time-consuming doctor visits and get continuous treatment plan improvements.
  • Track symptoms, medications and progress.
  • Regular clinical follow-ups to help you stay on track and keep getting better.
  • Track symptoms, medications and progress.
  • Take the quiz to see whether the DNA-guided treatment plan may be a good fit for you instead!
$50
once
Your medications delivered to your door and continuous access to expert care
  • Acute medication: starting at $10 per month.
  • Preventative medication: starting at $14 per month.
+ $16 Mable Care
per month
$
50
once
Specialist care
  • Individualized treatment plan
  • Expert diagnosis
  • HSA/FSA Eligible
  • Free shipping
$
399
once
DNA-guided specialist care
  • DNA-testing: prevent your migraines faster
  • Individualized treatment plan
  • Expert diagnosis
  • HSA/FSA Eligible
  • Free shipping

+ Mable Care (optional)

  • Talk to your physician anytime
  • Regular clinical follow-ups
  • Continuous treatment plan improvements
  • Acute or preventative medication
    starting at $26
    /month
  • Each additional medication
    from +$10
    /month

How Mable works

1

Take Mable’s DNA Test

Our DNA test is a fast, easy, and painless cheek swab that you can take at home. Mapping your DNA helps us identify which preventative migraine treatments will be best suited for you.
2

Complete our online medical assessment

This short consultation will help us better understand your migraine and medical history.
3

Receive a personalized plan

Your doctor will create the treatment plan suiting you best using the latest advances in genomic and clinical research. Treatment plans include acute, preventative and anti-nausea medications as well as supplements.
4

Get treatments delivered to your door

Mable delivers treatments to your door every three months in time before you run out of supply.
5

Keep getting better

Get regular medical follow-ups, access to your doctor within hours and continuous improvements to your treatment plan.

Mable uses science and physician-backed treatments to help you get better.

70%
60%
52

of members had tried ineffective treatment before Mable.

of people have genes that warrant caution for many preventative migraine treatments.

fewer migraine days per year for chronic migraine sufferers with the right medication on average.

The number one thing missing in migraine care have been biomarkers.
Dr. Carolyn Bernstein
Harvard Medical School
Mable Medical Board Member
Mable is supported by Harvard University.
Dr. Carolyn Bernstein - Mable Medical Board Member.
Your migraine is unique.
So why not treat it as such?

Mable's mission is to help you find migraine relief that works.

We, as Mable's founders, have migraines ourselves or have loved ones that do. We have experienced and been frustrated by the fight against migraines. Finding relief shouldn't be this hard.
Dr. Roman Rothaermel
CEO

Mable's Medical Board
Renowned migraine specialists

Peter Goadsby
Peter Goadsby
MD, PhD
President American Headache Society (2021)
University of California Los Angeles
Brain Prize Winner (2021)
Carolyn Bernstein
Carolyn Bernstein
MD, FAHS
Harvard Medical School
Author of The Migraine Brain
Morris Levin
Morris Levin
MD, FAHS
Director of University of California San Francisco Headache Center
Author of Understanding Your Migraines
Olivia Begasse De Dhaem
Olivia Begasse De Dhaem
MD, FAHS
Neurologist, Headache Medicine
Executive Editor for the Pain Medicine Journal

Join Maria and hundreds of other happy customers

Frequently asked questions

Why is Mable's approach faster and cheaper than the traditional route to migraine treatment?
What happens during DNA-guided treatment step by step?
Does Mable sell my DNA to third parties? (No, we don’t!)
Can I get personalized Migraine Care without the DNA-informed treatment plan?
Which conditions and medications are supported?
Can I use insurance to pay for Mable?
Membership details
How do refills work?
What states does Mable currently serve?
Should I cancel my prescriptions when I sign up for Mable?
Is Mable covered under HIPAA?
Can I use my FSA or HSA for payment?
Still have questions?
Please don’t hesitate to text or call us: +1 (855) 953 4316