Diagnosis and treatment from the migraine experts

Get the relief you need. Answer a few questions so that we can direct you toward getting better migraine care faster.
Mable Migraine Treatment Test PhotoMable Migraine Treatment Test Photo

With support from

Current migraine care often leads to a long trial-and-error process. Mable's team understands that the key to effective relief relies upon individualized treatment guided by a person's unique DNA and experience.
Dr. Carolyn Bernstein - Mable Medical Board Member.
Dr. Carolyn Bernstein
Harvard Medical School
Mable Medical Board Member

No one size fits all treatment.
Mable is one size fits you.

We recommend Mable to people who have tried less than 4 preventative migraine treatments and have not been prescribed CGRP inhibitors before.

Precision care using Mable’s DNA test is built specifically for people who are interested in preventative treatments in addition to acute medication.

If your dedicated doctor decides upon the first review of your information that Mable is not a good fit for you, you’ll get a 100% refund.
An image of a laptop.
1

Take Mable’s DNA Test

Our DNA test is a fast, easy, and painless cheek swab that you can take at home. Mapping your DNA helps us identify which preventative migraine treatments will be best suited for you.
An image of a laptop.
2

Complete our online medical assessment

This short consultation will help us better understand your migraine and medical history.
An image of a box.
3

Receive a personalized plan

Your doctor will create the treatment plan suiting you best using the latest advances in genomic and clinical research. Treatment plans include acute, preventative and anti-nausea medications as well as supplements.
An image of a letter with Mable's DNA-guided personalized migraine treatment.
4

Get treatments delivered to your door

Mable delivers treatments to your door every three months in time before you run out of supply.
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5

Keep getting better

Get regular medical follow-ups, access to your doctor within hours and continuous improvements to your treatment plan.
100% data privacy
We do not sell your data. We do not share your data with third parties other than for the sole purpose of analyzing, creating and fulfilling your personalized treatment plan. Samples collected through our at-home DNA test are analyzed in ISO and CLIA certified labs.
Continuous treatment improvements: after you receive your initial treatment plan, we keep screening your migraine and genetic information to match you with better treatment options once new evidence becomes available. Treatment improvements are included in your membership. You and your doctor will be notified. Our goal is to ensure that you always receive the best migraine care possible.

After you accept your treatment plan (you'll be notified via email), we ship a 90-day supply of your medication direct to your door. Payments are billed every 30 days after initial order. Memberships auto-renew every three months. Easy cancellation.

100% refund guarantee if no treatment recommendation can be issued or you are not happy with Mable.
Scientific rigor.
To ensure the scientific rigor of our testing process, we only use scientifically backed pharmacogenetic markers published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC). We regularly update our testing menu, once new solid scientific evidence becomes available.
Preventative medications.
In headache specialist clinics, most preventative migraine medications are prescribed "off-label". For instance, certain beta-blockers or antidepressants are routinely used to treat migraines. These medications have well documented pharmacogenetic associations and Mable enables physicians to leverage these to guide treatment based on DNA.
Medication
Covered by DNA-test
Amitriptyline
Yes
Nortriptyline
Yes
Propranolol
Yes
Metoprolol
Yes
Timolol
No
Venlafaxine
Yes
Candesartan
No
Verapramil
Yes
Topiramate
No
Galcanezumab
No
Anti-nausea medications.
These help reduce nausea accompanying a migraine attack.
Medication
Covered by DNA-test
Metochlopramide
Yes
Ondesarton
Yes
Prochlorperazine
No
Acute medications.
These are taken at the onset of a migraine attack to stop or reduce the pain. There are some painkillers that are highly specific for migraines. These include many different triptans such as Zolmitriptan, Almotriptan, Rizatriptan, Frovatriptan and Naratriptan. For this group of medications, there are no known genetic markers available to date. Fortunately, the choice of acute treatment can be informed by your specific migraine symptoms and medical history.
CGRP inhibitors (monoclonal antibodies).
CGRP (Calcitonin Gene-Related Peptide) inhibitors are a new class of medications to prevent and treat acute migraine pain. To date, there are no well established genetic markers to help predict a person's response to this group of medications. Mable and academic institutions are intensely researching this new field of migraine care and we will incorporate CGRP inhibitors into our testing process once strong scientific evidence becomes available.
Mable's test looks for 350+ SNPs (single nucleotide polymorphisms) that impact your body's response to migraine medications. This approach is called pharmacogenetic testing. Mable uses exclusively scientifically backed pharmacogenetic associations published by the FDA and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Knowledge of a patient's genotype can be used to guide a therapeutic strategy, determining an appropriate dosage, or assessing the likelihood of benefit or toxicity. We found that 60% of people with migraine have a genetic predisposition that would warrant caution with 8 or more standard migraine medications.

Mable's platform enables physicians for the first time to contextualize this pharmacogenetic information with your unique migraine symptoms in order to create a personalized treatment plan in accordance with your unique physiology.
Get better with clinically proven
treatment tailored to you.

Get better with clinically proven treatment tailored to you.

Mable’s Treatment Plans

HSA/FSA Eligible
Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.
POPULAR

DNA-guided specialist care

  • Individualized treatment plan based on your DNA and your unique migraine experience.
  • Shorten the path to migraine care that actually works for you.
  • mable checklist item
    Avoid potential years of trial-and-error looking for preventative medication.
  • Eliminate time-consuming doctor visits and get continuous treatment plan improvements.
  • Regular clinical follow-ups to help you stay on track and keep getting better.
  • Track symptoms, medications and progress.
  • Including rushed shipping to your door, return labels, DNA analysis, and individualized treatment plan.
$329
once

Specialist care

  • Individualized treatment plan based on your unique migraine experience.
  • Eliminate time-consuming doctor visits and get continuous treatment plan improvements.
  • Track symptoms, medications and progress.
  • Regular clinical follow-ups to help you stay on track and keep getting better.
  • Track symptoms, medications and progress.
  • Take the quiz to see whether the DNA-guided treatment plan may be a good fit for you instead!
$50
once
Your medications delivered to your door and continuous access to expert care
  • Acute medication: starting at $10 per month.
  • Preventative medication: starting at $14 per month.
+ $16 Mable Care
per month
$
29
Specialized care
Most affordable expert care
  • Expert doctor diagnosis & prescription
  • HSA/FSA eligible
  • 100% online so you're always in control
  • No insurance required
  • One-time fee
  • 100% satisfaction guarantee
$
279
Precision care
Most precise expert care
  • Everything in Specialized care
  • Precision treatment plan
  • DNA-testing: Examine 350+ SNPs to prevent your migraines faster
  • Scan your full genome to futureproof your migraine treatment
  • Early access to new relief breakthroughs
  • FREE priority shipping

+ Mable Care (optional)

  • Talk to your physician anytime
  • Regular clinical follow-ups
  • Continuous treatment plan improvements
  • Acute or preventative medication
    starting at $21
    /month
  • Premium access to migraine & headache tracking app
  • FREE! Fast shipping directly to your home

How Mable works

1
1

Complete our online medical assessment

This short consultation will help us better understand your migraine and medical history.
2
2

Take Mable’s DNA Test

Our DNA test is a fast, easy, and painless cheek swab that you can take at home. Mapping your DNA helps us identify which preventative migraine treatments will be best suited for you.
3
3

Receive a personalized plan

Your doctor will create the treatment plan suiting you best using the latest advances in genomic and clinical research. Treatment plans include acute, preventative and anti-nausea medications as well as supplements.
4
4

Get treatments delivered to your door

Mable delivers treatments to your door every three months in time before you run out of supply.
5
5

Keep getting better

Get personalized treatment instructions, regular follow-ups and access to your doctor and nurse team. We notify you and your doctor very time treatment options that may be a better fit for you emerge. Treatment changes included.

Mable uses science and physician-backed treatments to help you get better.

70%
60%
52

of members had tried ineffective treatment before Mable.

of people have genes that warrant caution for many preventative migraine treatments.

fewer migraine days per year for chronic migraine sufferers with the right medication on average.

Your migraine is unique.
So why not treat it as such?

Mable's mission is to help you find migraine relief that works.

We, as Mable's founders, have migraines ourselves or have loved ones that do. We have experienced and been frustrated by the fight against migraines. Finding relief shouldn't be this hard.
Dr. Roman Rothaermel
CEO

Mable's Medical Board
Renowned migraine specialists

Peter Goadsby
Peter Goadsby
MD, PhD
President American Headache Society (2021)
University of California Los Angeles
Brain Prize Winner (2021)
Carolyn Bernstein
Carolyn Bernstein
MD, FAHS
Harvard Medical School
Author of The Migraine Brain
Morris Levin
Morris Levin
MD, FAHS
Director of University of California San Francisco Headache Center
Author of Understanding Your Migraines
Olivia Begasse De Dhaem
Olivia Begasse De Dhaem
MD, FAHS
Neurologist, Headache Medicine
Executive Editor for the Pain Medicine Journal

Join Maria and hundreds of other happy customers

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Frequently asked questions

Why is Mable's approach faster and cheaper
than the traditional route to migraine treatment?
What happens during DNA-guided treatment step by step?
How does DNA-informed treatment work?
Who may not be a suitable candidate for the Mable treatment plan?
Does Mable sell my DNA to third parties? (No, we don’t!)
Can I get personalized Migraine Care without
the DNA-informed treatment plan?
Which conditions and medications are supported?
Can I use insurance to pay for Mable?
Membership details
How do refills work?
What states does Mable currently serve?
Should I cancel my prescriptions when I sign up for Mable?
Is Mable covered under HIPAA?
Can I use my FSA or HSA for payment?

Mable tests are eligible for reimbursement by most FSA and HSA plans. Since every plan is different, we advise that you check with your plan to confirm that the Mable test is eligible. Contact us at support@trymable.com to obtain an itemized receipt.

Still have questions?
Explore our help center or call us: +1 (855) 953 4316